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At present there is no cure for any of the mucopolysaccharide diseases . Enzyme replacement therapy (ERT)has been approved by the FDA for several of the MPS diseases, but ERT has not been shown to be effective in MPS III. Bone marrow transplants have been tried on individuals with MPS III, but with disappointing results. Gene therapy, chaperone therapy and intrathecal enzyme therapy are a few of the treatments for MPS III where research is ongoing .